Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish
نویسندگان
چکیده
منابع مشابه
Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish
Polyamines are small poly-cations essential for all cellular life. The main polyamines present in metazoans are putrescine, spermidine and spermine. Their exact functions are still largely unclear; however, they are involved in a wide variety of processes affecting cell growth, proliferation, apoptosis and aging. Here we identify idefix, a mutation in the zebrafish gene encoding the enzyme sper...
متن کاملSpermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase.
In our earlier work we showed that either spermidine or spermine could support the growth of spe2Delta or spe3Delta polyamine-requiring mutants, but it was unclear whether the cells had a specific requirement for either of these amines. In the current work, we demonstrate that spermidine is specifically required for the growth of Saccharomyces cerevisiae. We were able to show this specificity b...
متن کاملPutrescine, Spermidine, and Spermine
Putrescine was first isolated from putrifying meat and was thought of as a decomposition product; spermine was named from its occurrence in semen. These polyamines, however, are now known to have important roles in cell growth and differentiation. Their physiological significance can be studied by analyzing the consequences of depletion of the cellular polyamine content. The results include arr...
متن کاملSpermine and Spermidine
1Plant Breeding Institute, ARC, SF-31600 Jokioinen, Finland; 2Department of Genetics, SF-00014 University of Helsinki, Helsinki, Finland In a recent article describing the effects of various reaction conditions, Blanchard et al. ~1~ ment ioned that spermine and spermidine at concentrations between 0.5 and 3 mM had no effect on PCR amplification ~2'3> with their sequence-specific primers. Becaus...
متن کاملIs pigment cell pattern formation in zebrafish a game of cops and robbers?
Biological self-organization generates enormous diversity from relatively few conserved pathways controlling differential gene expression, raising the prospect that understanding extensive biological complexity relies, in turn, upon understanding relatively simple regulatory frameworks. Consequently, the regulation of biological self-organization has attracted enormous attention, not only from ...
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ژورنال
عنوان ژورنال: Biology Open
سال: 2016
ISSN: 2046-6390
DOI: 10.1242/bio.018721